DNA Replication and Recombination

DNA Replication and Recombination

Alberts, Bruce. Nature 421, no. 6921 (2003): 431-435.
https://doi.org/10.1038/nature01407

“DNA carries all of the genetic information for life. One enormously long DNA molecule forms each of the chromosomes of an organism, 23 of them in a human. The fundamental living unit is the single cell. A cell gives rise to many more cells through serial repetitions of a process known as cell division. Before each division, new copies must be made of each of the many molecules that form the cell, including the duplication of all DNA molecules. DNA replication is the name given to this duplication process, which enables an organism’s genetic information — its genes — to be passed to the two daughter cells created when a cell divides. Only slightly less central to life is a process that requires dynamic DNA acrobatics, called homologous DNA recombination, which reshuffles the genes on chromosomes. In reactions closely linked to DNA replication, the recombination machinery also repairs damage that inevitably occurs to the long, fragile DNA molecules inside cells.”

— Bruce Alberts